but if you extrapolate 6 or 7 anywhere in this equation, you must reconsider the square root of x in relation to the dopamine (DA) receptors which, given chronically to rats, induces a 32% increase in D1 receptor number and increases the Vmax of D1-stimulated striatal AC, resulted in marked resistance to acute morphine effects. the area of the Arbitrary Triangle relates exponentially to the Volemia and osmolality homeostasis that is ensured in vertebrates through neuroendocrine reflexes, involving an afferent neural branch from baro- and osmo-receptors to hypothalamus and an effer- ent endocrine branch from secretory neurons to target hydroosmotic cells equipped with receptors
and effecters. Whereas the osmoregulatory system in the tadpole comprises three organs, namely gut, kidney and gills, as in freshwater fishes, the adult displays a quaternary strategy with gut, kidney, urinary bladder and skin.

therefore, Secondary structure studies (circular dichroism, etc.) have shown that PRL is an all-␣-helix protein and contains almost 50% of ␣-helices, while the remainder of the protein appears to fold into nonorganized loop structures (23). To date, attempts to determine the three-dimensional structure of PRL via experimental techniques (x-ray, nuclear magnetic resonance) have been unsuccessful. However, taking advantage of the structure/function similarities between PRL and GH (see above), we have recently determined the 3D structure of hPRL using the homology modeling approach (24) based on the crystallographic coordinates of porcine (p) GH (25). As anticipated, hPRL is predicted to fold in a four-helix bundle and to share with GHs the particular up-up-down-down connectivity of the ␣-helices (9, 24 –26) and of course 0.